WHAT IT IS:

BBI WAS DISCOVERED BY DR. D. E. BOWMAN (UNIVERSITY OF CHICAGO) AND DR. Y. BIRK (WEIZMANN INSTITUTE OF SCIENCE, ISRAEL)— TWO PIONEERS IN PROTEIN BIOCHEMISTRY. THE MOLECULE WAS LATER NAMED BOWMAN–BIRK INHIBITOR IN HONOUR OF BOTH SCIENTISTS.

IT IS A NATURAL PROTECTIVE MOLECULE FOUND IN SOYBEANS AND LEGUMES, NOT A SYNTHETIC INVENTION. LATER RESEARCH FROM UCLA HIGHLIGHTED ITS STRONG CELLULAR PROTECTION EFFECTS CAUSED BY IRRITANTS.

THESE COMPOUNDS PROTECT TISSUES BY BLOCKING HARMFUL ENZYMES THAT BECOME OVERACTIVE DUE TO:

• SMOKING
• ALCOHOL EXPOSURE
• CHEWING TOBACCO
• CHRONIC IRRITATION
• OXIDATIVE STRESS AND INFLAMMATORY DAMAGE

WHEN THESE DESTRUCTIVE ENZYMES BECOME UNCONTROLLED, THEY DAMAGE EPITHELIAL CELLS AND CAN TRIGGER ABNORMAL CELL GROWTH. BBI WORKS BY SHUTTING DOWN THESE HARMFUL ENZYMES, HELPING YOUR CELLS STAY HEALTHY, BALANCED, AND PROTECTED.

IRRITATED ORAL MUCOSA (BEFORE BOWMAN–BIRK INHIBITOR ACTION)

PROBLEM STATE:

• RED, INFLAMED EPITHELIAL CELLS
• REACTIVE OXYGEN SPECIES (ROS) ATTACKING CELLS
• HIGH PROTEASE ACTIVITY (TINY “SCISSORS” DAMAGING CELL STRUCTURES)
• ONGOING IRRITATION FROM SMOKE/ ALCOHOL/ TOBACCO CHEMICALS
• DNA STRESS AND ABNORMAL KERATINISATION (EARLY LEUKOPLAKIA ENVIRONMENT)

BOWMAN–BIRK INHIBITOR REACHES THE ORAL SURFACE (LOCAL DELIVERY WITH BOYA10)

COATING PHASE:

• AFTER CHEWING, BOYA10 PHYTOTHERAPEUTIC PASTE COVERS CHEEKS, GUMS, TONGUE, PALATE
• BOWMAN-BIRK INHIBITOR MOLECULES SHOWN AS SHIELD-SHAPED ICONS
• THEY SETTLE DIRECTLY ONTO INFLAMED EPITHELIAL LAYERS

PROTEASE BLOCKING MECHANISM (CORE FUNCTION OF BOWMAN–BIRK INHIBITOR)

ACTION MODE:

BOWMAN–BIRK INHIBITOR IS A SERINE-PROTEASE INHIBITOR → IT BLOCKS HARMFUL ENZYMES THAT CAUSE

TISSUE BREAKDOWN.

FINAL EFFECT:

• LESS TISSUE DESTRUCTION
• SLOWER PROGRESSION TOWARD KERATIN PATCHES
• REDUCED IRRITATION CYCLE

CELLULAR DEFENCE ACTIVATION

PROTECTION PHASE:

BOWMAN–BIRK INHIBITOR ACTION LEADS TO:

• REDUCED CELLULAR STRESS
• IMPROVED EPITHELIAL STABILITY
• DECREASED DNA DAMAGE RISK
• INTERRUPTION OF THE INFLAMMATION-DAMAGE CYCLE
• RESTORATION OF HEALTHIER CELL TURNOVER

ANTI-PROLIFERATIVE SUPPORT (KEY ROLE IN ORAL LESIONS)

LONG-TERM DEFENCE:

BOWMAN–BIRK INHIBITOR SLOWS ABNORMAL CELL OVERGROWTH TRIGGERED

BY:

• SMOKE-RELATED NITROSAMINES
• ALCOHOL METABOLITES LIKE ACETALDEHYDE
• TOBACCO CARCINOGENS

VISUAL EFFECT:

 OVERGROWING THICK WHITE PATCH (LEUKOPLAKIA) SHRINKING

• NORMAL MUCOSAL THICKNESS RETURNING
• CELL LAYERS BECOMING UNIFORM AGAIN

FINAL OUTCOME – STABILISED & DEFENDED ORAL MUCOSA

MECHANISM (SIMPLE EXPLANATION):