HYDROXYPROPYL METHYLCELLULOSE

BOYA10 USES A HYDROXYPROPYL METHYLCELLULOSE SOFT CHEWABLE CAPSULE SHELL — A VEGETARIAN, INERT, AND FILM-FORMING POLYMER THAT RELIABLY RELEASES THE INTERNAL PHYTOTHERAPEUTIC PASTE ON CHEWING AND HELPS PRODUCE A UNIFORM PROTECTIVE COATING ON THE ORAL MUCOSA, IMPROVING LOCAL RETENTION OF ACTIVES THAT SUPPORT MUCOSAL COMFORT AND OXIDATIVE BALANCE.

WHAT IS HYDROXYPROPYL METHYLCELLULOSE?

HYDROXYPROPYL METHYLCELLULOSE IS A SEMI-SYNTHETIC, NON-IONIC CELLULOSE ETHER WIDELY USED IN PHARMACEUTICALS AS CAPSULE SHELLS, TABLET BINDERS AND FILM-FORMING POLYMERS. IT IS TASTELESS, CHEMICALLY STABLE, HEAT- AND MOISTURE-TOLERANT IN APPROPRIATE FORMULATIONS, AND COMMONLY USED IN VEGETARIAN/VEGAN CAPSULE SHELLS. INDUSTRY- AND REGULATORY ASSESSMENTS CLASSIFY HYDROXYPROPYL METHYLCELLULOSE AND RELATED CELLULOSE ETHERS AS SAFE FOR FOOD AND PHARMACEUTICAL USE WHEN MANUFACTURED TO SPECIFICATION.

WHY HYDROXYPROPYL METHYLCELLULOSE IS USED FOR BOYA10 CHEWABLE CAPSULES?

MATERIAL & MANUFACTURING ADVANTAGES

VEGETARIAN/VEGAN SHELL— UNLIKE GELATINE, HYDROXYPROPYL METHYLCELLULOSE IS PLANT-DERIVED AND SUITABLE FOR CONSUMERS AVOIDING ANIMAL PRODUCTS.
CHEMICAL INERTNESS & COMPATIBILITY — HYDROXYPROPYL METHYLCELLULOSE DOES NOT REACT WITH TYPICAL NUTRACEUTICAL ACTIVES AND PRESERVES INGREDIENT STABILITY.
GOOD MECHANICAL PROPERTIES — HYDROXYPROPYL METHYLCELLULOSE SHELLS CAN BE MANUFACTURED TO HAVE CONTROLLED BRITTLENESS SO THE SHELL BREAKS GENTLY ON CHEWING (DESIGNED BURST), RELEASING THE INNER PHYTOTHERAPEUTIC PASTE RELIABLY. INDUSTRY GUIDANCE AND SUPPLIER DATA DESCRIBE HYDROXYPROPYL METHYLCELLULOSE CAPSULE MECHANICAL TUNING FOR CHEWABLE PRODUCTS.

FORMULATION & FUNCTIONAL ADVANTAGES

FILM-FORMING AND GELATION — HYDROXYPROPYL METHYLCELLULOSE HYDRATES AND FORMS VISCOUS, COHESIVE GELS/FILMS ON CONTACT WITH SALIVA. THIS PROPERTY IS THE BASIS FOR MANY MUCOADHESIVE BUCCAL FILMS AND ENABLES BOYA10 PHYTOTHERAPEUTIC PASTE TO SPREAD EVENLY AND PERSIST ON MUCOSAL SURFACES. SEVERAL PUBLISHED BUCCAL FILM STUDIES USE HYDROXYPROPYL METHYLCELLULOSE AS THE PRIMARY FILM FORMER BECAUSE OF THESE PROPERTIES.
CONTROLLED RELEASE CAPABILITY — HYDROXYPROPYL METHYLCELLULOSE MATRICES CAN BE FORMULATED TO GIVE AN INITIAL BURST FOLLOWED BY SUSTAINED RELEASE OF ACTIVES; THIS IS EXPLOITED IN BUCCAL DELIVERY SYSTEMS TO MAINTAIN LOCAL EXPOSURE FOR MINUTES TO HOURS. THAT CONTROLLED LOCAL DELIVERY IMPROVES CONTACT TIME BETWEEN ANTIOXIDANTS/ACTIVES AND THE MUCOSA.
TASTE MASKING & TEXTURE CONTROL — HYDROXYPROPYL METHYLCELLULOSE SHELLS AND HYDROXYPROPYL METHYLCELLULOSE-BASED INNER MATRICES HELP MASK UNPLEASANT TASTES AND CREATE A CREAMY PHYTOTHERAPEUTIC PASTE TEXTURE ON RELEASE, IMPROVING USER ACCEPTABILITY FOR A CHEWABLE MUCOSAL COATING PRODUCT.

MECHANISM OF ACTION IN BOYA10

CONTROLLED MECHANICAL RELEASE: THE HYDROXYPROPYL METHYLCELLULOSE CHEWABLE SHELL IS ENGINEERED TO BREAK EASILY UNDER BITE PRESSURE, RELEASING THE INNER PHYTOTHERAPEUTIC PASTE RATHER THAN DISSOLVING IMMEDIATELY. THIS PRESERVES FULL PHYTOTHERAPEUTIC PASTE INTEGRITY UNTIL INTENTIONAL CHEWING. (MANUFACTURING AND CAPSULE DESIGN PRINCIPLES FOR HYDROXYPROPYL METHYLCELLULOSE CAPSULES.)

IMMEDIATE GELATION & FILM FORMATION: ON CONTACT WITH SALIVA THE PHYTOTHERAPEUTIC PASTE (CONTAINING HYDROXYPROPYL METHYLCELLULOSE-COMPATIBLE EXCIPIENTS AND ACTIVES) HYDRATES AND HYDROXYPROPYL METHYLCELLULOSE CONTRIBUTES TO FORMATION OF A VISCOUS SEMI-OCCLUSIVE FILM THAT SPREADS ACROSS CHEEKS, GUMS, TONGUE AND PALATE. HYDROXYPROPYL METHYLCELLULOSE’S FILM-FORMING BEHAVIOUR UNDERPINS MANY BUCCAL FILM PRODUCTS THAT STAY IN PLACE AND RELEASE DRUG/ACTIVES LOCALLY.

PROLONGED LOCAL RESIDENCE & CONTROLLED RELEASE: THE HYDROXYPROPYL METHYLCELLULOSE MATRIX SLOWS WASH-OFF BY SALIVA AND MECHANICAL MOVEMENT, THEREBY INCREASING LOCAL CONTACT TIME OF ANTIOXIDANTS (EPIGALLOCATECHIN-3-GALLATE, Α-TOCOPHEROL, BETA-CAROTENE) AND MUCOSAL ACTIVES (PHOSPHATIDYLCHOLINE, BBI). PROLONGED RESIDENCE IMPROVES LOCAL UPTAKE INTO EPITHELIAL LAYERS AND SUSTAINS ANTIOXIDANT NEUTRALIZATION AT THE TISSUE INTERFACE. PUBLISHED BUCCAL FILM STUDIES DEMONSTRATE HPMC-BASED FILMS CAN DELIVER ACTIVES LOCALLY FOR SEVERAL HOURS.

BARRIER & SOOTHING EFFECT: A HYDRATED HYDROXYPROPYL METHYLCELLULOSE FILM ACTS AS A TEMPORARY PROTECTIVE BARRIER THAT REDUCES DIRECT MECHANICAL AND CHEMICAL EXPOSURE OF MUCOSA TO IRRITANTS (HEAT, SMOKE, PARTICULATE MATTER), HELPS RETAIN MOISTURE, AND PROVIDES A VEHICLE FOR ACTIVES TO EXERT ANTIOXIDANT AND ANTI-INFLAMMATORY EFFECTS LOCALLY. WHILE HYDROXYPROPYL METHYLCELLULOSE ITSELF IS INERT, THE FILM FUNCTIONALLY REDUCES IMMEDIATE EXPOSURE AND SUPPORTS MUCOSAL COMFORT WHEN PAIRED WITH BIOACTIVES. (RATIONALE SUPPORTED BY BUCCAL FILM LITERATURE AND FILM-FORMING POLYMER SCIENCE.)

ROLE IN REDUCING THE LOCAL HARMFUL EFFECTS OF SMOKING / ALCOHOL / CHEWING TOBACCO — MECHANISTIC RATIONALE

WHAT HYDROXYPROPYL METHYLCELLULOSE DOES DIRECTLY:

FORMS A PHYSICAL SEMI-OCCLUSIVE FILM THAT TEMPORARILY SHIELDS MUCOSAL SURFACES FROM DIRECT THERMAL/CHEMICAL CONTACT (SMOKE HEAT, PARTICULATE DEPOSITION), LOWERING IMMEDIATE IRRITATION AND MOISTURE LOSS. FILM-FORMING PROPERTIES OF HPMC UNDERLIE MANY TOPICAL MUCOSAL DEVICES AND SUPPORT THIS BARRIER ROLE.

WHAT THE HYDROXYPROPYL METHYLCELLULOSE-BASED BOYA10 SYSTEM ENABLES:

IMPROVED LOCAL ANTIOXIDANT EXPOSURE: BY RETAINING EPIGALLOCATECHIN-3-GALLATE, Α-TOCOPHEROL AND Β-CAROTENE AT THE MUCOSAL SURFACE, THE HYDROXYPROPYL METHYLCELLULOSE FILM INCREASES LOCAL NEUTRALIZATION OF ROS PRODUCED BY TOBACCO AND ALCOHOL METABOLISM. CLINICAL BUCCAL FILM RESEARCH DEMONSTRATES THAT LOCAL DELIVERY ACHIEVES MEASURABLE LOCAL BIOMARKER MODULATION WITH LESS SYSTEMIC EXPOSURE.
ENHANCED EPITHELIAL CONTACT TIME FOR BARRIER REPAIR ACTIVES: PHOSPHATIDYLCHOLINE AND FOLATE BENEFIT FROM PROLONGED MUCOSAL CONTACT TO INTEGRATE INTO MEMBRANES AND SUPPORT CELL TURNOVER; THE HYDROXYPROPYL METHYLCELLULOSE MATRIX INCREASES THAT CONTACT TIME VERSUS A SWALLOWED TABLET. (MECHANISTIC RATIONALE SUPPORTED BY BUCCAL DELIVERY LITERATURE.)

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