PTEROYLGLUTAMIC ACID — ROLE IN BOYA10 LOCAL ORAL MUCOSAL COATING TECHNOLOGY

BIOLOGIC MECHANISMS — HOW FOLATE SUPPORTS ORAL MUCOSA
 
 
  • DNA SYNTHESIS AND REPAIR (ONE-CARBON METABOLISM): PTEROYLGLUTAMIC ACID PROVIDES ONE-CARBON UNITS REQUIRED FOR NUCLEOTIDE (THYMIDYLATE & PURINE) SYNTHESIS. ADEQUATE FOLATE PREVENTS URACIL MISINCORPORATION INTO DNA AND SUPPORTS ACCURATE DNA REPLICATION AND REPAIR IN RAPIDLY RENEWING EPITHELIAL TISSUES SUCH AS ORAL MUCOSA. THIS REDUCES REPLICATION STRESS AND THE RISK OF MUTATION ACCUMULATION IN SURFACE EPITHELIAL CELLS.
  • METHYLATION AND GENE REGULATION: PTEROYLGLUTAMIC ACID SUPPLIES METHYL GROUPS (VIA S-ADENOSYLMETHIONINE PATHWAY) THAT ARE ESSENTIAL FOR DNA AND HISTONE METHYLATION. PROPER METHYLATION HELPS MAINTAIN NORMAL GENE EXPRESSION PROGRAMS IN EPITHELIAL DIFFERENTIATION AND PREVENTS ABERRANT ACTIVATION OF PROLIFERATION PATHWAYS.
  • SUPPORT FOR CELL PROLIFERATION & WOUND HEALING: PTEROYLGLUTAMIC ACID DEFICIENCY SLOWS EPITHELIAL CELL PROLIFERATION AND IMPAIRS RE-EPITHELIALIZATION. SUPPLEMENTATION IN MUCOSAL INJURY MODELS INCREASES MARKERS OF PROLIFERATION (EGFR, KI-67) AND ANGIOGENESIS DURING HEALING, SUPPORTING FASTER MUCOSAL REPAIR. THIS HAS BEEN SHOWN IN GASTRIC MUCOSAL MODELS AND OTHER EPITHELIAL TISSUES.
  • ANTI-INFLAMMATORY AND ANTIOXIDANT MODULATION: EXPERIMENTAL DATA INDICATE FOLATE CAN MODULATE INFLAMMATORY CYTOKINE PROFILES (REDUCING TNF-Α AND IL-1Β; INCREASING IL-4/IL-10 IN SOME MODELS) AND REDUCE OXIDATIVE DAMAGE, CREATING A MORE FAVOURABLE HEALING MICROENVIRONMENT.
 
WHY FOLATE INSIDE BOYA10’S LOCAL COATING IS LOGICAL
 
 
  • LOCAL CONCENTRATION AT THE SITE OF NEED: ORAL EPITHELIAL CELLS ARE THE DIRECT TARGET FOR MUCOSAL REGENERATION. DELIVERING FOLATE TOPICALLY (VIA A PHYTOTHERAPEUTIC PASTE THAT ADHERES TO CHEEK, GUMS, TONGUE AND PALATE) CAN INCREASE LOCAL AVAILABILITY TO EPITHELIAL CELLS BEFORE SYSTEMIC DILUTION OR FIRST-PASS METABOLISM REDUCES EFFECTIVE TISSUE EXPOSURE. THIS IS ESPECIALLY RELEVANT WHEN THE GOAL IS LOCAL MUCOSAL SUPPORT, NOT SYSTEMIC NUTRITION. (MECHANISTIC RATIONALE; DIRECT TOPICAL FOLATE TRIALS IN ORAL LESIONS ARE LIMITED; DATA EXIST FOR MUCOSAL HEALING IN OTHER TISSUES).
  • SYNERGY WITH OTHER ACTIVES IN BOYA10: FOLATE SUPPORTS CELL REPLICATION AND REPAIR WHILE ANTIOXIDANTS (EPIGALLOCATECHIN-3-GALLATE, Α-TOCOPHEROL, Β-CAROTENE) REDUCE OXIDATIVE DAMAGE AND PHOSPHATIDYLCHOLINE HELPS REPAIR MEMBRANES — TOGETHER THEY CREATE A MICROENVIRONMENT CONDUCIVE TO MUCOSAL HEALING.
  • SHORT CONTACT, MEANINGFUL EFFECT: BOYA10’S ADHESION (MINUTES OF CONTACT) MAY BE ENOUGH TO INCREASE EPITHELIAL UPTAKE OF FOLATE IN SUPERFICIAL LAYERS WHERE CELL DIVISION AND REPAIR OCCUR — USEFUL FOR DAILY MAINTENANCE OR RECOVERY FROM CHRONIC IRRITATION.

 

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